Marie Lazarre Kashpaw is the wife of Nector Kashpaw and a central figure to Love Medicine. She is known for her motherly qualities and has many biological and adopted children, including Gordie, Zelda, Aurelia, Eugene, Patsy, a boy and girl who die in their youth, her grandson Lipsha Morrissey, briefly June Morrissey and many adopted children. She is somewhat ostracized because of her white heritage and her relation to the Lazarre Family. She has struggles with her mother-in-law Margaret Kashpaw and her fellow nun Sister Leopolda, who unknown to her was her biological mother.

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